Immunopathological investigations during the course of arthritis induced in rats by Streptococcus agalactiae.

摘要: A large single intraperitoneal injection of sonicated cells Streptococcus agalactiae O90R induced polyarthritis in Wistar rats. The arthritis reaction score was monitored according to redness, edema, severity and deformity rat ankle wrist joints. inflammation joints confirmed by radiology histology. Acute initiated within 48 h the chronic form continued for more than 30 days. Although serum immunoglobulin elevated h, anti-streptococcal antibody detected only at later times (by enzyme-linked immunosorbent assay Arthus-type hypersensitivity reactions) neither nor splenocytes arthritic rats were able transfer disease susceptible, normal From these observations finding streptococcal antigen joint macrophages immunogold labelling) we conclude that is related persistent fragments rather or immune complexes.