Treatment of experimental erosive arthritis in rats by injection of the muralytic enzyme mutanolysin.
作者： M J Janusz , C Chetty , R A Eisenberg , W J Cromartie , J H Schwab
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摘要: A single intravenous injection into rats of 0.4 mg the muralytic enzyme mutanolysin, given as long 3 d after an arthropathic dose peptidoglycan-polysaccharide polymers derived from group streptococci (PG-APS), resulted in a complete resolution acute arthritis and prevention chronic joint disease. When administration mutanolysin was delayed until 14 PG-APS, great reduction severity inflammation still observed. Quantitation amount PG-APS present limbs, spleen, liver by solid phase enzyme-linked immunoassay indicated that tissues mutanolysin-treated contained much PBS-treated control rats. In addition, treated with immediately receiving intraperitoneal developed transient limb edema similar to seen digested small fragment size vitro mutanolysin. We hypothesize acts vivo degrading fragments persist but are no longer arthropathic.
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