Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation.
作者： Flavia R. S. Lima , Camila P. Arantes , Angelita G. Muras , Regina Nomizo , Ricardo R. Brentani
DOI: 10.1111/J.1471-4159.2007.04904.X
关键词: Cell signaling 、 Extracellular matrix 、 Neurite 、 Laminin 、 Cell–cell interaction 、 Cell biology 、 Neuroglia 、 Astrocyte 、 Neuroscience 、 Biology 、 Cellular differentiation
摘要: The functions of cellular prion protein (PrP(C)) are under intense debate and PrP(C) loss function has been implicated in the pathology diseases. Neuronal engagement with stress-inducible protein-1 laminin (LN) plays a key role cell survival differentiation. present study evaluated whether expression astrocytes modulates neuron-glia cross-talk that underlies neuronal Astrocytes from wild-type mice promoted higher level neuritogenesis than obtained PrP(C)-null animals. Remarkably, was greatly diminished co-cultures combining neurons. LN secreted deposited at extracellular matrix by presented fibrillary pattern permissive for neuritogenesis. Conversely, coming displayed punctate distribution, did not support Additionally, soluble factors lower levels those astrocytes. were characterized as molecules which participate survival. Taken together, these data indicate is critical sustaining cell-to-cell interactions, organization matrix, secretion factors, all essential events differentiation
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