Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation.
作者： Naushira Pandya , Roberta DeMott-Friberg , Cyril Y. Bowers , Ariel L. Barkan , Craig A. Jaffe
关键词: Internal medicine 、 Somatropin 、 Area under the curve 、 Secretagogue 、 Peptide hormone 、 Hypothalamus 、 Medicine 、 Hormone 、 Bolus (medicine) 、 Blood plasma 、 Endocrinology
摘要: GH-releasing peptide-6 (GHRP-6) is a potent GH secretagogue that releases by uncertain mechanisms. To assess whether GHRH required for release GHRP-6 in humans, we used the specific antagonist to (N-Ac-Tyr1,d-Arg2)GHRH(1–29)NH2 (GHRH Ant). We have previously shown GHRH-Ant (400 μg/kg) blocked response 0.33 and 3.3 μg/kg boluses of 95% 81%, respectively. Nine healthy men between ages 20 30 yr were studied on two occasions. They received either saline or μg/kg, iv) at 0840 h, followed (1μ g/kg, iv bolus) 0900 h. Blood was sampled every 10 min from 0800–1100 responses measured as maximal increase over baseline concentration area under curve. eliminated most [maximal concentration, 33.8 ± 4.8 vs. 6.2 1.8 μg/L (mean ±sem; P< 0.0001); curve, 1701 278 376 113 μg/min·L (P < 0.001)]. These data show e...
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