Perforin-like Immunoreactivity in Four Cases of Lymphoma of Large Granular Lymphocytes in the Cat

摘要: Tumors composed of discrete round cells with large eosinophilic granules in their cytoplasm were observed four cats. These cats presented severe gastrointestinal signs, including anorexia, vomiting, and diarrhea. The exploratory laparotomy two necropsy the other revealed thickening perforation intestinal walls, enlargement mesenteric, ileocolic, and/or colic lymph nodes, splenomegaly. Histologically, there was disseminated infiltration tumor affected organs. In necropsied, spleen jejunal mucosa appeared to be primary organs involved. all showed pore-forming protein (perforin)-like immunoreactivity unique cytotoxic lymphocytes but failed show histamine immunoreactivity. results indicate that derived from granular perforinlike may a useful marker for histologic diagnosis feline ...