The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
作者： Ming Zheng , Haili Zhang , David L. Dill , J. David Clark , Susan Tu
DOI: 10.1371/JOURNAL.PMED.1001782
关键词: Molecular genetics 、 Allele 、 Extrapyramidal symptoms 、 Genetic predisposition 、 Toxicity 、 Inbred strain 、 Biology 、 Pharmacology 、 Haloperidol 、 Genetic model
摘要: Background We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability optimally utilize existing drugs or develop new for CNS disorders. For example, haloperidol is a potent dopamine antagonist that used treat psychotic disorders, but 50% of treated patients characteristic extrapyramidal symptoms caused by haloperidol-induced toxicity (HIT), which limits its clinical utility. We do not have any information toxicity. HIT in humans directly mirrored murine model, where inbred mouse strains are differentially susceptible HIT. Therefore, we genetically analyzed model performed translational human association study.
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