Succinate: A New Epigenetic Hacker
作者： Ming Yang , Patrick J. Pollard
DOI: 10.1016/J.CCR.2013.05.015
关键词: Genetics 、 Gene 、 DNA methylation 、 Cancer epigenetics 、 Demethylase 、 Reprogramming 、 Succinate dehydrogenase 、 Histone 、 Biology 、 Epigenetics 、 Cancer research
摘要: Epigenetic reprogramming is a feature of many human cancers. In this issue Cancer Cell, Letouze and colleagues describe DNA hypermethylation in paragangliomas harboring mutations succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone demethylase enzymes, resulting epigenetic silencing that affects neuroendocrine differentiation.
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