Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

作者: Evanna L. Mills , Beth Kelly , Angela Logan , Ana S.H. Costa , Mukund Varma

DOI: 10.1016/J.CELL.2016.08.064

关键词: Carbonyl cyanide m-chlorophenyl hydrazoneCitric acid cycleRespiratory chainAlternative oxidaseATP synthaseOxidative phosphorylationSuccinate dehydrogenaseBiochemistryBiologyMitochondrion

摘要: … Importantly, succinate and malonate were the only two metabolites significantly altered by the addition of DMM in the presence or absence of LPS, demonstrating specificity (Figures S3A…

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