Macrophage Metabolism Shapes Angiogenesis in Tumors
作者： Alberto Mantovani , Massimo Locati
DOI: 10.1016/J.CMET.2016.10.016
关键词:
摘要: In this issue, Wenes et al. (2016) show that genetic deletion of REDD1, an mTOR inhibitor induced by hypoxia, enhances glycolysis in tumor-associated macrophages (TAMs). Metabolic competition for glucose between TAMs and endothelial cells prevents the formation abnormal, leaky vascular network. Thus, targeting REDD1 stabilizes network inhibits metastasis.
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