Arachidonic acid metabolism by lipoxygenase pathways in intrauterine tissues of women at term of pregnancy
作者： Murray D. Mitchell , Camille F. Grzyboski
DOI: 10.1016/0262-1746(87)90119-3
关键词: Amnion 、 Leukotriene B4 、 Cyclooxygenase 、 Lipoxygenase 、 Endocrinology 、 Biology 、 Decidua 、 Arachidonic acid 、 Placenta 、 Internal medicine 、 Fetus
摘要: Abstract Intrauterine tissues from women at term of pregnancy metabolized arachidonic acid by way lipoxygenase pathways that included 5-, 12-, and 15- lipoxygenases. The major product formed amnion obtained before labor was leukotriene B 4 after 12-hydroxyeicosatetraenoic (12-HETE). Chorion laeve decidua vera synthesized predominantly 15-HETE all times placenta produced mainly 12-HETE. Trends existed for increased prostaglandin formation with amnion, chorion laeve, placenta. It is suggested products metabolism cyclooxygenase play significant roles in the control fetal uteroplacental hemodynamics mechanism(s) parturition.
uq.edu.au
core.ac.uk
elsevier.com参考文章(21)
C N Serhan, J Fridovich, E J Goetzl, P B Dunham, G Weissmann, Leukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes. Journal of Biological Chemistry. ,vol. 257, pp. 4746- 4752 ,(1982) , 10.1016/S0021-9258(18)34588-5
G. D. Thorburn, J. R. Challis, Endocrine control of parturition Physiological Reviews. ,vol. 59, pp. 863- 918 ,(1979) , 10.1152/PHYSREV.1979.59.4.863
J M Bailey, R W Bryant, J Whiting, K Salata, Characterization of 11-HETE and 15-HETE, together with prostacyclin, as major products of the cyclooxygenase pathway in cultured rat aorta smooth muscle cells. Journal of Lipid Research. ,vol. 24, pp. 1419- 1428 ,(1983) , 10.1016/S0022-2275(20)37865-2
John Turk, Angela Wyche, Philip Needleman, Inactivation of vascular prostacyclin synthetase by platelet lipoxygenase products Biochemical and Biophysical Research Communications. ,vol. 95, pp. 1628- 1634 ,(1980) , 10.1016/S0006-291X(80)80085-4
D. G. Payan, A. Missirian-Bastian, E. J. Goetzl, Human T-lymphocyte subset specificity of the regulatory effects of leukotriene B4. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 81, pp. 3501- 3505 ,(1984) , 10.1073/PNAS.81.11.3501
Salvador Moncada, Ryszard J. Gryglewski, Stuart Bunting, John R. Vane, A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation Prostaglandins. ,vol. 12, pp. 715- 737 ,(1976) , 10.1016/0090-6980(76)90048-4
G. C. Liggins, Christine S. Forster, Susan A. Grieves, A. L. Schwartz, Control of Parturition in Man Biology of Reproduction. ,vol. 16, pp. 39- 56 ,(1977) , 10.1095/BIOLREPROD16.1.39
R. Carraher, R. Carraher, D.W. Hahn, D.M. Ritchie, J.L. McGuire, Involvement of lipoxygenase products in myometrial contractions Prostaglandins. ,vol. 26, pp. 23- 32 ,(1983) , 10.1016/0090-6980(83)90071-0
Valerie M. Parisi, John H.G. Rankin, Terrance M. Phernetton, Edgar L. Makowski, The effect of a leukotriene receptor antagonist, FPL 55712, on estrogen-induced uterine hyperemia in the nonpregnant rabbit American Journal of Obstetrics and Gynecology. ,vol. 148, pp. 365- 369 ,(1984) , 10.1016/0002-9378(84)90708-7
Louis M. Pelus, Helen R. Strausser, Prostaglandins and the immune response Life Sciences. ,vol. 20, pp. 903- 913 ,(1977) , 10.1016/0024-3205(77)90274-0