Prostaglandins and the immune response

摘要: Abstract The experimental evidence amply demonstrates that exogenous Pg is capable of inhibiting most immunological functions. physiological role Pgs in immune cell regulation, however, remains unresolved. This uncertainty arises from the fact although are normally found tissues nanogram quantities or less, many experiments which demonstrate mediated inhibition usually employ at least one thousand- fold larger. In such experiments, results, obviously reflect pharmacological rather than effects. view literature reviewed here, following statements summarize implicate a role: 1. A. inhibit responsiveness. 2. B. Immune and non-immune cells secrete response to various stimuli. 3. C. possess receptors for Pgs. 4. D. Indomethacin enhances function tumor-bearing antigen-challenged mice. recent indications may mediate their effects through cyclic endoperoxides non-prostanoate metabolites prove be an important challenge proposed roles At this time, no definitive exists compounds other classical active inhibition.