Therapeutic effects of hydrogen in animal models of Parkinson's disease.
作者： Kyota Fujita , Yusaku Nakabeppu , Mami Noda
DOI: 10.4061/2011/307875
关键词: Programmed cell death 、 Mechanism (biology) 、 Bioinformatics 、 Medicine 、 Animal studies 、 Dopaminergic 、 Oxidative stress 、 Disease 、 MPTP 、 Parkinson's disease
摘要: Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for …
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