The Metabolism and Pharmacokinetics of Alcohol in Man
作者： P.W. Mullen
DOI: 10.1016/S0015-7368(77)71115-6
关键词: Forensic toxicology 、 Cofactor 、 Kinetics 、 Pharmacology 、 NAD+ kinase 、 Pharmacokinetics 、 Chemistry 、 Metabolism 、 Biochemistry 、 Alcohol
摘要: Recent advances in the metabolism and pharmacokinetics of alcohol are reviewed. The by cellular dehydrogenases leads to an increased NADH/NAD cofactor ratio, which turn alters normal biochemical processes. elimination from body is best described terms Michaelis-Menten rather than zero-order kinetics. parameters V max K m "typical" 70kg man appear be approximately 25·0mg/(100ml×hr) 10·5mg/100ml, respectively. merits pharmacokinetic principles forensic toxicology discussed briefly.
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scienceandjusticejournal.com 参考文章(21)
OA Forsander, Influence of the metabolism of ethanol on the lactate/pyruvate ratio of rat-liver slices. Biochemical Journal. ,vol. 98, pp. 244- 247 ,(1966) , 10.1042/BJ0980244
D. Keilin, E. F. Hartree, Properties of catalase. Catalysis of coupled oxidation of alcohols. Biochemical Journal. ,vol. 39, pp. 293- 301 ,(1945) , 10.1042/BJ0390293
Charles S. Lieber, Leonore M. DeCarli, Hepatic Microsomal Ethanol-oxidizing System: IN VITRO CHARACTERISTICS AND ADAPTIVE PROPERTIES IN VIVO Journal of Biological Chemistry. ,vol. 245, pp. 2505- 2512 ,(1970) , 10.1016/S0021-9258(18)63099-6
John E. Dowd, Douglas S. Riggs, A COMPARISON OF ESTIMATES OF MICHAELIS-MENTEN KINETIC CONSTANTS FROM VARIOUS LINEAR TRANSFORMATIONS. Journal of Biological Chemistry. ,vol. 240, pp. 863- 869 ,(1965) , 10.1016/S0021-9258(17)45254-9
John G. Wagner, Paul K. Wilkinson, Allen J. Sedman, Donald R. Kay, Donald J. Weidler, Elimination of Alcohol from Human Blood Journal of Pharmaceutical Sciences. ,vol. 65, pp. 152- 154 ,(1976) , 10.1002/JPS.2600650142
Philip R. Steinmetz, Christine Balko, Charles S. Lieber, Liver Adaptation and Injury in Alcoholism New England Journal of Medicine. ,vol. 288, pp. 356- 362 ,(1973) , 10.1056/NEJM197302152880710
A. Huntley Blair, Bert L. Vallee, Some Catalytic Properties of Human Liver Alcohol Dehydrogenase Biochemistry. ,vol. 5, pp. 2026- 2034 ,(1966) , 10.1021/BI00870A034
A. K. Rawat, Effects of Ethanol Infusion on the Redox State and Metabolite Levels in Rat Liver in vivo FEBS Journal. ,vol. 6, pp. 585- 592 ,(1968) , 10.1111/J.1432-1033.1968.TB00485.X
Mark A. Korsten, Shohei Matsuzaki, Lawrence Feinman, Charles S. Lieber, High Blood Acetaldehyde Levels after Ethanol Administration New England Journal of Medicine. ,vol. 292, pp. 386- 389 ,(1975) , 10.1056/NEJM197502202920802
Charles S. Lieber, The Metabolism of Alcohol Scientific American. ,vol. 234, pp. 25- 32 ,(1976) , 10.1038/SCIENTIFICAMERICAN0376-25