Effect of Polymer Permeability and Solvent Removal Rate on In Situ Forming Implants: Drug Burst Release and Microstructure.
作者： Xiaowei Zhang , Liqun Yang , Chong Zhang , Danhua Liu , Shu Meng
DOI: 10.3390/PHARMACEUTICS11100520
关键词: Dissolution 、 Solvent 、 Polymer degradation 、 Polycaprolactone 、 Trimethylene carbonate 、 Depot 、 Polymer 、 Chemistry 、 Triacetin 、 Chemical engineering
摘要: To explore the mechanism of drug release and depot formation in situ forming implants (ISFIs), osthole-loaded ISFIs were prepared by dissolving polylactide, poly(lactide-co-glycolide), polycaprolactone, or poly(trimethylene carbonate) different organic solvents, including N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin (TA). Drug release, polymer degradation, solvent removal rate microstructure examined. The burst effect could be reduced using solvents exhibit slow phase inversion less permeable polymers. Both closely related to solvent. Polymers with higher permeability often displayed faster diffusion rates. Due high polymer-solvent affinity, some remained even after implant was completely formed. residual predicted solubility parameters. ISFI showed a lower initial vivo than that vitro. In summary, effects polymers on systems extensively investigated discussed this article. two main factors, rate, involved stages systems.
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