Tissue expression, structure and function of the murine Ly-6 family of molecules.

摘要: Murine Ly-6 molecules are a family of cell surface glycoproteins which have interesting patterns tissue expression during haematopoiesis from multipotential stem cells to lineage committed precursor cells, and on specific leucocyte subpopulations in the peripheral lymphoid tissues. These suggest an intimate association between regulation development homeostasis immune system. low molecular weight phosphatidyl inositol anchored with remarkable amino acid homology throughout distinctive cysteine rich protein domain that is associated predominantly O-linked carbohydrate. encoded by multiple tightly linked genes located Chr. 15 conserved geneomic organization. The vivo functions not known although vitro studies role cellular activation. This review will summarize our understanding regard expression, structure, gene organization function.