THE ROLE OF STEM CELL ANTIGEN-1(Sca-1) IN MUSCLE AGING
作者： Sonia Angela Richards-Malcolm
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摘要: OF THESIS THE ROLE STEM CELL ANTIGEN-1(Sca-1) IN MUSCLE AGING Muscle aging is associated with a decrease in the number of satellite cells and their progeny, muscle progenitor (MPCs) that are available for repair regeneration. However, there an increase non-immuno-hematopoietic (CD45 negative) regenerating from aged mice characterized by high stem cell antigen -1(Sca-1) expression. In muscle, 14.2% CD45 neg Sca-1 pos while 7.2% young adult muscle. vitro, over express genes fibrosis, potentially controlled Wnt2. These proliferative, non-myogenic non-adipogenic, arise clonally-derived MPCs cultures mice. Both vitro vivo studies suggest more susceptible to apoptosis than MPCs, which may contribute depletion pool. Therefore, age, subset takes on altered phenotype, marked This phenotype prevents these participating regeneration or replenishing pool, instead fibrosis
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