Worsening of lipid metabolism after successful treatment of primary aldosteronism.

摘要: Primary aldosteronism (PA) describes the most frequent cause of secondary arterial hypertension. Recently, deterioration lipid metabolism after adrenalectomy (ADX) for aldosterone-producing adenoma (APA) has been described. We analysed longitudinal changes in profiles a large prospective cohort PA patients. Data 215 consecutive patients with APA (n = 144) or bilateral idiopathic adrenal hyperplasia (IHA, n = 71) were extracted from database German Conn's Registry. Patients investigated before and 1 year successful treatment by ADX mineralocorticoid receptor antagonists (MRA). Glomerular filtration rate (GFR), fasting plasma glucose components including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C) high-density (HDL-C) determined at 8.00 12-h period. One year initiation mean serum potassium levels blood pressure normalized HDL-C TG developed inversely decreasing (p = .046) IHA (p = .004) increasing (APA p = .000; p = .020). BMI remained unchanged improved (p = .004). Furthermore, there was significant decrease GFR both subgroups follow-up (p = .000). Changes correlated multivariate analysis (p = .024). Treatment is associated parameters despite stable pressure. This effect can be explained renal dysfunction following MRA therapy.