Identification of Risk Factors for Early Neoplasm

摘要: Inflammation, especially chronic inflammation, is a significant factor in the development of solid tumor malignancies (2). Several inflammation markers, including interleukin 6 (IL-6), C-reactive protein (CRP), and amyloid protein, can be detected blood circula­tion serve as risk factors for early neoplasm. CRP nonspecific but most sensitive marker inflammation. IL-6, IL-1, necrosis alpha induce synthesis hepatocytes. Its role predictor survival has been shown multiple myeloma, melanoma, lymphoma, ovarian, renal, pancreatic, gastrointestinal tumors (3). Chronic infection by viruses, bacteria, parasites, chemical irritants, nondigestible particles, or nonin­fectious sources all may result major cancer. The longer persists, higher associated carcinogenesis. It well known that during phagocytosis bacteria virus-infected cells, powerful mixture oxidants such nitric oxide (NO), O2 H2O2 are released. These from cause oxidative damage to DNA, leading mutations eventually carcinogenesis (4).