Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women.

摘要: Objectives: To explore the relationship between serum homocysteine, a sensitive biomarker for folate inadequacy and problems in one-carbon metabolism, invasive cervical cancer. Methods: A large case–control study was conducted five US areas with up to two community controls, obtained by random-digit dialing, individually matched each case. Cervical cancer risk factors were assessed through at-home interview. Blood drawn at least 6 months after completion of treatment from 51% 68% interviewed cases controls. Serum homocysteine measured high-performance liquid chromatography, exposure human papillomavirus (HPV) type 16, most prevalent oncogenic type, using an enzyme-linked immunosorbent assay. Cases advanced and/or receiving chemotherapy excluded, leaving 183 540 Results: Invasive substantially elevated women upper three quartiles (>6.31μmol/L); multivariate-adjusted odds ratios ranged 2.4 3.2 (all 95% CIs excluded 1.0). trend apparent significant (p=0.01). When compared HPV-16 seropositive controls only, comparable. Conclusions: strongly significantly predictive risk. This association could reflect folate, B12 B6 inadequacy, or genetic polymorphisms affecting metabolism.