Vitamins B6, B12, and Folate: Association with Plasma Total Homocysteine and Risk of Coronary Atherosclerosis
作者： Petra Verhoef , Frans J. Kok , Patty W. Siri
DOI: 10.1080/07315724.1998.10718790
关键词:
摘要: Objectives: To investigate the association of status vitamins B6, B12 and folate with plasma fasting total homocysteine (tHcy) risk coronary atherosclerosis; to establish whether associations between atherosclerosis are mediated by tHcy.Methods: The study population consisted 131 patients angiographically-defined severe 88 referents no or minor stenosis. Previous analyses in this have shown that tHcy is an independent factor for atherosclerosis. In present analyses, using multiple linear regression, we estimated differences concentrations subjects lowest highest quartiles each vitamins, adjusting age, gender, total:HDL cholesterol ratio, smoking habits, alcohol intake, blood pressure, serum creatinine, body mass index two other vitamins. We used logistic regression analysis conditional on set of...
narcis.nl
core.ac.uk参考文章(30)
J. E. Rossouw, D. Labadarios, G. S. Shephard, P. L. Jooste, Lack of a relationship between plasma pyridoxal phosphate levels and ischaemic heart disease. South African Medical Journal. ,vol. 67, pp. 539- 541 ,(1985)
W.J.H Vermaak, H.C Barnard, G.M Potgieter, H du T. Theron, Vitamin B6 and coronary artery disease. Epidemiological observations and case studies. Atherosclerosis. ,vol. 63, pp. 235- 238 ,(1987) , 10.1016/0021-9150(87)90126-2
B A Myers, M A Dubick, R D Reynolds, R B Rucker, Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups. Biochemical Journal. ,vol. 229, pp. 153- 160 ,(1985) , 10.1042/BJ2290153
Lori A. Smolin, N. J. Benevenga, Accumulation of Homocyst(e)ine in Vitamin B-6 Deficiency: a Model for the Study of Cystathionine β-Synthase Deficiency Journal of Nutrition. ,vol. 112, pp. 1264- 1272 ,(1982) , 10.1093/JN/112.7.1264
Lori A. Smolin, T. D. Crenshaw, D. Kurtycz, N. J. Benevenga, Homocyst(e)ine accumulation in pigs fed diets deficient in vitamin B-6: relationship to atherosclerosis. Journal of Nutrition. ,vol. 113, pp. 2022- 2033 ,(1983) , 10.1093/JN/113.10.2022
T Fiskerstrand, H Refsum, G Kvalheim, P M Ueland, Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clinical Chemistry. ,vol. 39, pp. 263- 271 ,(1993) , 10.1093/CLINCHEM/39.2.263
Carol J. Boushey, A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease JAMA. ,vol. 274, pp. 1049- 1057 ,(1995) , 10.1001/JAMA.1995.03530130055028
JOEL B. MASON, JOSHUA W. MILLER, The effects of vitamins B12, B6, and folate on blood homocysteine levels. Annals of the New York Academy of Sciences. ,vol. 669, pp. 197- 203 ,(1992) , 10.1111/J.1749-6632.1992.TB17100.X
N Pancharuniti, C A Lewis, H E Sauberlich, L L Perkins, R C Go, J O Alvarez, M Macaluso, R T Acton, R B Copeland, A L Cousins, T B Gore, P E Cornwell, J M Roseman, Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. The American Journal of Clinical Nutrition. ,vol. 59, pp. 940- 948 ,(1994) , 10.1093/AJCN/59.4.940
M Azam Mansoor, Claes Bergmark, Asbjørn M Svardal, Per Eystein Lønning, Per M Ueland, None, Redox status and protein binding of plasma homocysteine and other aminothiols in patients with early-onset peripheral vascular disease. Homocysteine and peripheral vascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 15, pp. 232- 240 ,(1995) , 10.1161/01.ATV.15.2.232