Effect of vitamin B-6 (pyridoxine) deficiency on lung elastin cross-linking in perinatal and weanling rat pups.

摘要: Weanling and perinatal rats were rendered vitamin B-6 (pyridoxine)-deficient. The rat pups nursed from B-6-deficient or -sufficient dams killed at day 15 after parturition. weanling fed diets 5 weeks of treatment. Lung elastin the groups was then studied with respect to its content lysine-derived cross-linking amino acids. lysyl oxidase activity also measured. deficiency decreased number lysine residues in that converted into acid precursor allysine. However, a more significant defect cross-link formation an apparent block condensation steps leading desmosine. Desmosine decreased, increase amounts aldol products (aldol CP) elastin. It is proposed elevation CP results thiazines, which are produced reaction between aldehyde homocysteine. concentration homocysteine significantly elevated rats.