The effects of vitamins B12, B6, and folate on blood homocysteine levels.

摘要: The interaction between plasma homocysteine levels and vitamins B6, B12, folate is an exciting field one that has gathered great momentum over the past few years, with recognition probably plays important role in occlusive vascular disease. Our understanding this greatly advanced compared to just a years ago. There are number of issues, however, will need be addressed future if we develop sufficient knowledge base effectively minimize risk disease ascribable hyperhomocysteinemia. These include (1) definitive evidence actual agent mediates accelerated mechanism by which occurs; (2) what constitutes pathologic elevation (is there threshold concentration below no injury occurs? peak achieved critical determinant injury, or area under curve, some other feature, more important?); (3) synergies might exist adding B6 B12 regimen supplementation (what doses most appropriate? toxologic issues limit utility supplementation?); (4) determining circumstances where reduction retard reverse process