Homocysteine, Folic Acid, and Cardiovascular Disease Risk

摘要: Key Points The balance of homocysteine and methionine in the body can be disturbed because low folic acid, B12, or B6 intake activity several enzymes under genetic control. In United States, plateau maximal lowering that attained by acid fortification enriched flour grain products has not yet been achieved. Inferences from meta-analyses restricted to prospective observational studies consistently point a small elevated risk coronary heart disease (CHD) associated with higher levels homocysteine. Similarly, an independent effect is found on cerbrovascular peripheral vascular disease. Most evidence suggests CHD relatively common homozygotes (approx 10%) for methylene tetrahydrofolate reductase C677T polymorphism (i.e., those two copies cytosine thymine mutation at neucleotide 677), among borderline folate status. Trials secondary prevention are expected provide concerning preventive potential homocysteine.