Folate, vitamin B12, and homocysteine status. findings of no relation between human papillomavirus persistence and cervical dysplasia.

摘要: Abstract Objectives Human papillomavirus (HPV) infections are the cause of most, if not all, cervical cancers. Women consistently positive for oncogenic type HPV have a greater risk developing dysplasia compared with women transiently infected. infection alone appears to be insufficient produce disease, suggesting that other cofactors may needed. Folate, vitamin B12, and homocysteine, through their role in DNA methylation, involved neoplasia. Methods This study examined associations between persistence circulating folate, homocysteine levels among 91 low-income Hispanic women. Further, relation these nutrients pathology was evaluated. status determined at two visits approximately 3 mo apart. Results Adjusted mean concentrations were statistically different tests, one test, or negative tests. No association observed tertiles risk. adjusted cytologic grades. Conclusions from this small did support dysplasia.