Nutritional and Genetic Inefficiencies in One-Carbon Metabolism and Cervical Cancer Risk

摘要: Folate deficiency has long been postulated to play a role in the etiology of cervical cancer, third most frequent cancer among women worldwide. In large, multiethnic community-based case-control study invasive five U.S. areas, we assessed accepted and risk factors with an in-home interview successfully obtained blood samples, at least 6 mo after completion treatment, from 51 68%, respectively, interviewed cases controls. Cases advanced disease (6%) and/or receiving chemotherapy (4%) were excluded, leaving 183 540 Serum red cell folate measured both microbiologic radiobinding assays. For all four measures, was moderately, but nonsignificantly, elevated for lowest quartile, compared highest [fully adjusted relative risks (RR), including serologic human papillomavirus (HPV)-16 status = 1.2-1.6]. However, upper three homocysteine quartiles (>6.31 μmol/L), substantially significantly (fully RR, HPV-16 2.4-3.2; P trend 0.01). This strong relationship suggesis that circulating may be 1) especially accurate indicator inadequate folate, 2) integratory measure insufficient tissues or 3) biomarker disruption one-carbon metabolism. The contribution common polymorphisms pathway genes, as well vitamin B-6, B-12 riboflavin, homocysteine, inefficient metabolism increased merits further exploration.