miRNA-155 and miRNA-181a as prognostic biomarkers for pediatric acute lymphoblastic leukemia.
作者： Nashwa El‐Khazragy , Mohamed Ahmed Noshi , Camelia Abdel‐Malak , Rasha F. Zahran , Menha Swellam
DOI: 10.1002/JCB.27918
关键词: Internal medicine 、 Lymphoma 、 Oncology 、 Pathogenesis 、 Leukemia 、 Mortality rate 、 Childhood Acute Lymphoblastic Leukemia 、 microRNA 、 Medicine 、 Drug resistance 、 Minimal residual disease
摘要: Mortality rates of acute lymphoblastic leukemia (ALL) have improved over the past 20 years; however, a significant portion deaths stems from lack prognostic biomarkers, which can direct therapy and overcome drug resistance. microRNA-155a (miRNA-155a) miRNA-181a are two single-stranded miRNAs involved in pathogenesis many types lymphoma is linked to We investigated their expression levels 55 patients, 45 diagnosed with ALL 10 as control group. found that miRNA-155a were significantly upregulated group both being high minimal residual disease poor prognosis. cutoff value was discriminating between high- low-risk patients well healthy controls, value, not significant. Both markers downregulated after therapy. conclude miR-155 correlated prognosis ALL, whereas we couldn't link ALL. Moreover, marked decrease could reflect impact on outcome.
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