Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1

作者: K. Jones , J. Kadonaga , P. Luciw , R Tjian

DOI: 10.1126/SCIENCE.3008338

关键词: Long terminal repeatPromoterTranscription (biology)RNARetrovirusBiologyMolecular biologyBinding siteTranscription factorTranscriptional regulation

摘要: … In this study it is shown that the mammalian Sp1 transcription factor binds to promoter … Sp1 binding sites of variable affinity. Base-substitution mutations targeted to one or all three Sp1 …

参考文章(41)
F. Brun-Vezinet, F. Barre-Sinoussi, A.G. Saimot, D. Christol, L. Montagnier, C. Rouzioux, D. Klatzmann, W. Rozenbaum, J.C. Gluckmann, J.C. Chermann, DETECTION OF IgG ANTIBODIES TO LYMPHADENOPATHY-ASSOCIATED VIRUS IN PATIENTS WITH AIDS OR LYMPHADENOPATHY SYNDROME The Lancet. ,vol. 323, pp. 1253- 1256 ,(1984) , 10.1016/S0140-6736(84)92444-9
R. Gallo, S. Salahuddin, M Popovic, G. Shearer, M Kaplan, B. Haynes, T. Palker, R Redfield, J Oleske, B Safai, al. et, Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS Science. ,vol. 224, pp. 500- 503 ,(1984) , 10.1126/SCIENCE.6200936
F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, W Rozenbaum, L Montagnier, Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. ,vol. 220, pp. 868- 871 ,(1983) , 10.1126/SCIENCE.6189183
Mark A. Muesing, Douglas H. Smith, Cirilo D. Cabradilla, Charles V. Benton, Laurence A. Lasky, Daniel J. Capon, Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature. ,vol. 313, pp. 450- 458 ,(1985) , 10.1038/313450A0
D Gidoni, J. Kadonaga, H Barrera-Saldana, K Takahashi, P Chambon, R Tjian, Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science. ,vol. 230, pp. 511- 517 ,(1985) , 10.1126/SCIENCE.2996137
David J. Galas, Albert Schmitz, DNAase footprinting a simple method for the detection of protein-DNA binding specificity Nucleic Acids Research. ,vol. 5, pp. 3157- 3170 ,(1978) , 10.1093/NAR/5.9.3157
A. ElKareh, A. J. Murphy, T. Fichter, A. Efstratiadis, S. Silverstein, "Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 1002- 1006 ,(1985) , 10.1073/PNAS.82.4.1002
J. McDougal, M. Kennedy, J. Sligh, S. Cort, A Mawle, J. Nicholson, Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule Science. ,vol. 231, pp. 382- 385 ,(1986) , 10.1126/SCIENCE.3001934