Central nicotinic acetylcholine receptors in the chicken and Drosophila CNS: biochemical and molecular biology approaches.
作者： Heinrich Betz , Eckart D. Gundelfinger , Irm Hermans-Borgmeyer , Erich Sawruk , Patrick Schloß
DOI: 10.1007/978-3-0348-9138-7_18
关键词: Binding site 、 Antagonist 、 Nicotinic agonist 、 Flux (metabolism) 、 Acetylcholine receptor 、 Membrane protein 、 Molecular biology 、 Nicotinic acetylcholine receptor 、 Chemistry 、 Cholinergic
摘要: Putative neuronal nicotinic acetylcholine receptors (nAChRs) were investigated using biochemical and molecular biology approaches. In the chick visual system, a cholinergic binding site was localized on polypeptide of Mr 57 000 potent antagonist, α-bungarotoxin (α-Btx). Ion flux experiments indicate that this membrane protein is different from toxin-insensitive nAChR present in vertebrate neurons.
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