A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food.

作者: S.P. Li , C.F. Qiao , Y.W. Chen , J. Zhao , X.M. Cui

DOI: 10.1016/J.CHROMA.2013.07.025

关键词: Economic shortageNotoginsenoside R1Ginsenoside Rg1Hplc methodPanax notoginsengFunctional foodChemistryChromatographyPharmacologyBiochemical engineeringQuality (business)

摘要: Root of Panax notoginseng (Burk.) F.H. Chen (Sanqi in Chinese) is one traditional Chinese medicines (TCMs) based functional food. Saponins are the major bioactive components. The shortage reference compounds or chemical standards main bottlenecks for quality control TCMs. A novel strategy, i.e. standardized extract qualification and single calibrated components directly quantitative estimation multiple analytes, was proposed to easily effectively natural foods such as Sanqi. feasibility credibility this methodology were also assessed with a developed fast HPLC method. Five saponins, including ginsenoside Rg1, Re, Rb1, Rd notoginsenoside R1 rapidly separated using conventional 20 min. quantification method compared individual calibration curve strategy feasible credible, which adapted improving

参考文章(24)
J. Guan, C.M. Lai, S.P. Li, A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra performance liquid chromatography Journal of Pharmaceutical and Biomedical Analysis. ,vol. 44, pp. 996- 1000 ,(2007) , 10.1016/J.JPBA.2007.03.032
Jin-Jun Hou, Wan-Ying Wu, Juan Da, Shuai Yao, Hua-Li Long, Zhou Yang, Lu-Ying Cai, Min Yang, Xuan Liu, Bao-Hong Jiang, De-An Guo, Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard Journal of Chromatography A. ,vol. 1218, pp. 5618- 5627 ,(2011) , 10.1016/J.CHROMA.2011.06.058
Jie Li, Zhi-Zhong Xie, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan, Ginsenoside-Rd, a purified component from panax notoginseng saponins, prevents atherosclerosis in apoE knockout mice. European Journal of Pharmacology. ,vol. 652, pp. 104- 110 ,(2011) , 10.1016/J.EJPHAR.2010.11.017
Soojeong Jang, Yunsook Lim, Giuseppe Valacchi, Sungbin Sorn, Hyon Park, Na-Young Park, Myoungsook Lee, Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice. Genes and Nutrition. ,vol. 7, pp. 319- 329 ,(2012) , 10.1007/S12263-011-0245-7
Chong-Zhi Wang, Eryn McEntee, Sheila Wicks, Ji-An Wu, Chun-Su Yuan, Phytochemical and analytical studies of Panax notoginseng (Burk.) F.H. Chen Journal of Natural Medicines. ,vol. 60, pp. 97- 106 ,(2006) , 10.1007/S11418-005-0027-X
ZM Qian, JB Wan, QW Zhang, SP Li, None, Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography Journal of Pharmaceutical and Biomedical Analysis. ,vol. 48, pp. 1361- 1367 ,(2008) , 10.1016/J.JPBA.2008.09.038
Jian‐Bo Wan, Peng Li, Shaoping Li, Yitao Wang, Tina Ting‐Xia Dong, Karl Wah‐Keung Tsim, None, Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction. Journal of Separation Science. ,vol. 29, pp. 2190- 2196 ,(2006) , 10.1002/JSSC.200600103
Shu Zhu, Kun Zou, Hirotoshi Fushimi, Shaoqing Cai, Katsuko Komatsu, Comparative study on triterpene saponins of Ginseng drugs. Planta Medica. ,vol. 70, pp. 666- 677 ,(2004) , 10.1055/S-2004-827192
Hong Bo Guo, Xiu Ming Cui, Na An, Ge Ping Cai, Sanchi ginseng ( Panax notoginseng (Burkill) F. H. Chen) in China: distribution, cultivation and variations Genetic Resources and Crop Evolution. ,vol. 57, pp. 453- 460 ,(2010) , 10.1007/S10722-010-9531-2