Numerical Study of Granular Scaffold Efficiency to Convert Fluid Flow into Mechanical Stimulation in Bone Tissue Engineering

摘要: Controlling the mechanical environment in bioreactors represents a key element reactors' optimization. Positive effects of fluid flow three-dimensional have been observed, but local stresses at cell scale remain unknown. These led to development numerical tools assess micromechanical cells bioreactors. Recently, new possible scaffold geometry has emerged: granular packings. In present study, primary goal was compare efficiency such other ones from literature terms wall shear stress levels and distributions. To that aim, three different types packings were generated through discrete method, computational dynamics used simulate within these Shear distributions determined. A linear relationship between inlet velocity its slope similar published data. The normalized independent highly comparable those widely porous scaffolds. Granular features more classical scaffolds advantage being easy manipulate seed. methods this work are generalizable study packing configurations.