Increased sodium appetite in the rat induced by intracranial administration of components of the renin-angiotensin system.

摘要: 1. Intracranial injections of components the renin-angiotensin system in rats normal water and Na balance caused an immediate thirst followed by a progressive increase appetite during test session which lasted 18 h. The effect on intake was dose-dependent. 2. Long-term (7 day) infusions angiotensin II into third cerebral ventricle at rates 1 or 10 pmol h-1 produced large sustained increases 2 . 7% NaCl. Intakes sometimes exceeded 100 ml NaCl per day but quickly fell to when infusion stopped. 3. injection carbachol transient had no 4. induced intracranial specific for since offered choice equimolar concentrations KCl took only This resembles pattern seen Na-depleted rats. 5. Increased not secondary increased it occurred available drink. 6. natriuresis since, first, angiotensin-stimulated went positive balance, secondly, renin did cause excretion Na-loaded thirdly, anureic showed significant response renin. 7. These results suggest that brain may play role development appetite.