Immune parameters in the intestine of wild and reared unvaccinated and vaccinated Atlantic salmon (Salmo salar L.).

作者: Guro Løkka , Lars Austbø , Knut Falk , Erin Bromage , Per Gunnar Fjelldal

DOI: 10.1016/J.DCI.2014.06.009

关键词: Recombination-activating geneVaccinationGastrointestinal tractZoologyPopulationBiologyIntestinal morphologyMHC class IIImmunologyImmune systemSalmo

摘要: Abstract Forming a barrier to the outside world, gut mucosa faces challenge of absorbing nutrients and fluids while initiating immune reactions towards potential pathogens. As continuation our previous publication focusing on regional intestinal morphology in wild caught post smolt spawning Atlantic salmon, we here investigate selected parameters compare wild, reared unvaccinated vaccinated smolts. We observed highest transcript levels for most immune-related genes smolts followed by finally smolts, indicating that farming conditions like commercial feed vaccination might contribute more alerted system gut. In all groups, higher transcripts were second segment mid-intestine posterior segment. life stages investigated here, found no indication previously suggested population T cells expressing MHC class II nor RAG1 expression.

参考文章(57)
R K Buddington, A M Bakke-Mckellep, A Krogdahl, The intestines of carnivorous fish: structure and functions and the relations with diet Acta Physiologica Scandinavica. ,vol. 638, pp. 67- 80 ,(1997)
Guro L⊘kka, Lars Austb⊘, Knut Falk, Inge Bjerkås, Erling Olaf Koppang, Intestinal morphology of the wild Atlantic salmon (Salmo salar). Journal of Morphology. ,vol. 274, pp. 859- 876 ,(2013) , 10.1002/JMOR.20142
Erling O. Koppang, Uwe Fischer, Lindsey Moore, Michael A. Tranulis, Johannes M. Dijkstra, Bernd Köllner, Laila Aune, Emilio Jirillo, Ivar Hordvik, Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue Journal of Anatomy. ,vol. 217, pp. 728- 739 ,(2010) , 10.1111/J.1469-7580.2010.01305.X
Erling O. Koppang, Inge Bjerkås, Erlend Haugarvoll, Edward K. L. Chan, Nancy J. Szabo, Nobutaka Ono, Bunshiro Akikusa, Emilio Jirillo, Trygve T. Poppe, Harald Sveier, Brit Tørud, Minoru Satoh, Vaccination-Induced Systemic Autoimmunity in Farmed Atlantic Salmon Journal of Immunology. ,vol. 181, pp. 4807- 4814 ,(2008) , 10.4049/JIMMUNOL.181.7.4807
Adrian Hayday, Efstathios Theodoridis, Elizabeth Ramsburg, John Shires, Intraepithelial lymphocytes: exploring the Third Way in immunology. Nature Immunology. ,vol. 2, pp. 997- 1003 ,(2001) , 10.1038/NI1101-997
A. Zapata, C. T. Amemiya, Phylogeny of lower vertebrates and their immunological structures. Current Topics in Microbiology and Immunology. ,vol. 248, pp. 67- 107 ,(2000) , 10.1007/978-3-642-59674-2_5
L A Steiner, P Greenhalgh, C E Olesen, Characterization and expression of recombination activating genes (RAG-1 and RAG-2) in Xenopus laevis. Journal of Immunology. ,vol. 151, pp. 3100- 3110 ,(1993)
L.Sigve Håvarstein, Per M. Aasjord, Signe Ness, Curt Endresen, Purification and partial characterization of an IgM-like serum immunoglobulin from atlantic salmon (Salmo salar) Developmental & Comparative Immunology. ,vol. 12, pp. 773- 785 ,(1988) , 10.1016/0145-305X(88)90052-3
Hilde Cheroutre, Florence Lambolez, Daniel Mucida, The light and dark sides of intestinal intraepithelial lymphocytes Nature Reviews Immunology. ,vol. 11, pp. 445- 456 ,(2011) , 10.1038/NRI3007