Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma.

摘要: Hemangioma is a common benign tumor in the childhood; however our knowledge about molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been shown as gene expression regulators with an important role disease pathogenesis. Our goals were to identify miRNA-mRNA networks associated infantile hemangioma. We performed meta-analysis previously published datasets including 98 samples. Deregulated genes further used potential Data integrated using bioinformatics methods, mapped proteins, which then construct protein-protein interaction networks. play roles cell growth differentiation, signaling, angiogenesis vasculogenesis. Regulatory identified included miR-9, miR-939 let-7 family; these showed most number interactions deregulated hemangioma, suggesting that they may disease. Additionally, results drug-gene druggable categories Drug-Gene Interaction Database. show microRNA-target be useful biomarkers for novel therapeutic strategies patients microRNA-regulated pathways potentially future