Zinc levels after iron supplementation in patients with chronic kidney disease

摘要: Abstract Objective The goal of this study was to evaluate the effects iron supplementation on zinc distribution in nondialyzed chronic kidney disease (CKD) patients. Design Prospective nonrandomized observational study. Setting Outpatients Nephrology Division at Federal University Sao Paulo. Patients Zinc and status 38 patients (63% male; creatinine clearance, 34.5±13.3 mL/min/1.73 m 2 ) evaluated before after 3 intramuscular injections 100 mg each. Main outcome measures following parameters were analyzed: erythrocytes plasma zinc, protoporphyrin (ZPP), ferritin, transferrin saturation (TFS), total iron. patients' diets analyzed by Association Official Analytical Chemists method for macronutrients, neutron activation analysis used concentration determinations. Results Ferritin TFS increased from 86.3±67.5 ng/mL 105.4±63.7 19.5±7.4% 23.2±6.7% ( P = .08). At baseline, erythrocyte 49.0±7.6 μg Zn/gHb, 76.3% had high concentration. After treatment, decreased 45.5±7.3 Zn/gHb .001). No significant change observed ZPP diet showed energy protein intakes 26.2±7.1 kcal/kg/day 0.89±0.2 g/kg/day, respectively, a low intake both zinc. Conclusions This suggests that deficiency may contribute inadequate with CKD decrease abnormal elevated levels these