Lysine-based amino-functionalized lipids for gene transfection: the influence of the chain composition on 2D properties.
作者： Stephanie Tassler , Dorota Pawlowska , Christopher Janich , Bodo Dobner , Christian Wölk
DOI: 10.1039/C8CP00047F
关键词: Polymer chemistry 、 Langmuir 、 Lysine 、 Protonation 、 Amine gas treating 、 Absorption spectroscopy 、 Chemistry 、 Double bond 、 Monolayer 、 Cis–trans isomerism
摘要: The influence of the chain composition on physical–chemical properties will be discussed for five transfection lipids containing same lysine-based head group. For this purpose, gradually varied from saturated tetradecyl (C14:0) and hexadecyl (C16:0) chains to longer but unsaturated oleyl (C18:1) with double bonds in cis configuration. In work, we investigated as Langmuir monolayers at air–water-interface absence presence calf thymus DNA applying different techniques such infrared reflection absorption spectroscopy (IRRAS) grazing incidence X-ray diffraction (GIXD). replacement by increases fluidity lipid monolayer: TH10 < TT10 OH10 OT10 OO10 resulting a smaller packing density. forms stiffest most fluid monolayer structure–property study. has higher protonation degree compared well hybrids because better accessibility amine groups. Depending bulk pH, scenarios coupling have been proposed.
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