Do we know how to diagnose epilepsy early in Alzheimer's disease?

作者: B. Cretin , N. Philippi , O. Bousiges , L. Dibitonto , F. Sellal

DOI: 10.1016/J.NEUROL.2017.03.028

关键词: Temporal lobePediatricsGeneralized epilepsyDementiaComorbidityPsychiatryDiseasePsychologyElectroencephalographyAlzheimer's diseaseEpilepsy

摘要: Epilepsy is an increasingly recognized comorbidity in Alzheimer's disease (AD). First described as generalized dementia patients, epileptic AD patients are nowadays fully earlier stages of the (with mild or subjective cognitive impairment). At such early stages, may present not only with seizures, but also focal seizures (commonly localized frontal temporal lobe). Thus, partial epilepsy part semiological spectrum that should be borne mind at all to ensure identification and prevent risk repeated (such accidents, injury, progression This review available (and still growing) literature shows there already sufficient data inform physicians on seizure semiology, diagnostic value electroencephalography brain imaging. Taken together, these tools can help rapidly identify patients. Nevertheless, diagnosis challenging, test medication sometimes necessary. Some cerebrospinal fluid biomarkers (or their ratios) prove good predictors AD, further studies needed. frequently pharmacosensitive, a response obtained standard doses antiepileptic drugs. For reasons based our literature, it appears that, present, possible any stage disease, recommended improve patient's prognosis.

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