Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes
作者： Lumine Matsumoto , Tomotaka Yamamoto , Mana Higashihara , Izumi Sugimoto , Hisatomo Kowa
DOI: 10.1002/MDS.21314
关键词: Limbic encephalitis 、 Parkinsonism 、 Carcinoma in situ 、 Intratubular germ cell neoplasia 、 Pathology 、 Medicine 、 Germ cell neoplasm 、 Orchiectomy 、 Encephalitis 、 Central nervous system disease
摘要: We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of microscopic “carcinoma in situ” the testis. The young age patient, along progressive neurologic deterioration, detection anti-Ma2 antibodies, and ultrasound findings bilateral microcalcifications, led to orchiectomy, revealing tumor both testes. After neurological symptoms stabilized, but patient eventually died systemic complications caused by his deficits. Anti-Ma2 encephalitis should be considered patients hypokinesis, intensive investigation aggressive approach treatment is encouraged prevent progression
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