miRNAs in Cancer Stem Cells
作者： Yiwei Li , Dejuan Kong , Aamir Ahmad , Bin Bao , Fazlul H. Sarkar
DOI: 10.1016/B978-0-12-405544-5.00005-8
关键词: Cellular differentiation 、 microRNA 、 Hedgehog 、 Organogenesis 、 Cancer stem cell 、 Stem cell 、 Cell biology 、 Biology 、 Wnt signaling pathway 、 Metastasis
摘要: Abstract microRNAs, or miRNAs, play critical roles in cell differentiation and organogenesis by regulating stem self-renewal differentiation. They are important regulators of cancer formation, survival, growth, their aberrant expression may increase drug resistance promote invasion metastasis. miRNAs regulate TGF-β, Wnt, notch, hedgehog signal transductions, which development Targeted miRNA regulation synthetic oligonucleotides, novel agents, nutraceuticals that inhibit differentiation, combination with conventional chemotherapeutics, promises better treatment outcomes.
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