The function of c-fms in hairy-cell leukemia: macrophage colony- stimulating factor stimulates hairy-cell movement
作者： J Burthem , PK Baker , JA Hunt , JC Cawley
DOI: 10.1182/BLOOD.V83.5.1381.1381
关键词: Cytokine 、 Macrophage colony-stimulating factor 、 Cell biology 、 Immunology 、 Hairy Cell 、 Video microscopy 、 Motility 、 Biology 、 Integrin 、 Alpha-v beta-3 、 Hairy cell leukemia
摘要: Hairy cells (HCs) and some activated B express high levels of macrophage colony-stimulating factor (M-CSF) (CSF-1) receptor, but the functional effects cytokine on have not been previously identified. Using video microscopy, image analysis, migration assays, M-CSF was shown to induce chemokinetic chemotactic movement HCs. This response involved transition a highly mobile, rounded cell form accompanied by distinctive changes in F-actin polymerization distribution. Furthermore, M-CSF-induced motility substantially modified adhesive protein used as substratum qualitative function alpha v beta 3 integrin It is suggested that findings are relevant pathophysiology hairy-cell leukemia (HCL) particular, biology B-cell general.
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