NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity
作者： John L.R. Rubenstein , Maike Sander , Roger A. Pedersen , Michael S. German , Juanito J. Meneses
DOI:
关键词: Depression (differential diagnoses) 、 Internal medicine 、 Biology 、 Diabetes mellitus 、 Genetically modified mouse 、 Gene 、 Function (biology) 、 Endocrinology 、 Obesity
摘要: The present invention features mouse models for Nkx-2.2 gene function and Nkx-6.1 function, wherein the transgenic is characterized by having a defect in or (where, because acts upstream of Nkx-6.1, affects function) decreased number insulin-producing cells relative to normal mouse. Where contains further serotonin-producing mice may be either homozygous heterozygous defect.
lens.org 参考文章(10)
Nora Sarvetnick, Pancreatic growth and regeneration Karger Landes Systems. ,(1997)
S. W. Wilson, Katrin Anukampa Barth, Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain Development. ,vol. 121, pp. 1755- 1768 ,(1995) , 10.1242/DEV.121.6.1755
John L R Rubenstein, Dennis J. Hartigan, Salvador Martinez, Luis Puelles, Kenji Shimamura, Longitudinal organization of the anterior neural plate and neural tube Development. ,vol. 121, pp. 3923- 3933 ,(1995) , 10.1242/DEV.121.12.3923
A. Rudnick, T. Y. Ling, H. Odagiri, W. J. Rutter, M. S. German, Pancreatic beta cells express a diverse set of homeobox genes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 12203- 12207 ,(1994) , 10.1073/PNAS.91.25.12203
Dennis J. Hartigan, John L.R. Rubenstein, The cDNA sequence of murine Nkx-2.2 Gene. ,vol. 168, pp. 271- 272 ,(1996) , 10.1016/0378-1119(95)00745-8
Hiroshi Inoue, Abraham Rudnick, Michael S. German, Rosalie Veile, Helen Donis-Keller, M.Alan Permutt, Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene. Genomics. ,vol. 40, pp. 367- 370 ,(1997) , 10.1006/GENO.1996.4568
Kozo Kaibuchi, Toshihiko Ogura, Shun Nakamura, Masato Nakafuku, Tadahiro Kaneko, Ken Ichi Arai, Yasushi Nakagawa, Masaaki Torii, Taiga Suzuki, ROLES OF CELL-AUTONOMOUS MECHANISMS FOR DIFFERENTIAL EXPRESSION OF REGION-SPECIFIC TRANSCRIPTION FACTORS IN NEUROEPITHELIAL CELLS Development. ,vol. 122, pp. 2449- 2464 ,(1996) , 10.1242/DEV.122.8.2449
M. Sander, Michael S. German, The β cell transcription factors and development of the pancreas Journal of Molecular Medicine. ,vol. 75, pp. 327- 340 ,(1997) , 10.1007/S001090050118
Easterlin Ra, Fertility and development. Population bulletin of the United Nations Economic Commission for Western Asia. ,vol. 18, pp. 5- 40 ,(1980)
R. Vidaltamayo, M. Hiriart, D. Castanares, T. Rosenbaum, H. E. Lopez-Valdes, Experimental and Clinical Endocrinology and Diabetes conference. ,(1997)