Methods and compositions using fgf23 fusion polypeptides

摘要: The present disclosure is directed to methods, kits and compositions for preventing or treating age-related conditions metabolic disorders. fusion polypeptides of the include FGF23 an active fragment thereof. In one embodiment, polypeptide comprises (a) a comprising fibroblast growth factor 23 (FGF23), functionally variant derivative thereof, wherein has mutation at more positions Q 156, C206 C244; (b) either modified Fc having decreased affinity Fc-gamma-receptor and/or increased serum half-life, least extracellular subdomain Klotho protein, thereof; and, optionally (c) linker. proteins are useful in treatment prevention variety another FGF (such as FGF23), fragment, various embodiments polypeptides, mutations which decrease aggregation protease-mediated cleavage.