Influence of carriers on the development and localization of anti-2,4,6-trinitrophenyl (TNP) antibody-forming cells in the murine spleen. II. Suppressed antibody response to TNP-Ficoll after elimination of marginal zone cells.
作者： Eric Claassen , Nel Kors , Nico Van Rooijen
关键词: Molecular biology 、 Keyhole limpet hemocyanin 、 Immunology 、 Antigen 、 Biology 、 Ficoll 、 Immune tolerance 、 Marginal zone 、 Antibody 、 Spleen 、 Immune system
摘要: The macrophages in the marginal zones mice spleens were eliminated by i.v. injection of dichloromethylene diphosphonate encapsulated liposomes. After immunization with a thymus-dependent (trinitrophenylated keyhole limpet hemocyanin; TNP-KLH) or thymus-independent type 1 (TNP-lipopolysaccharide) antigen, no differences antibody responses treated and untreated observed. However, 2 (TI-2) antigen (TNP-Ficoll) resulted strong decrease response macrophage-depleted animals. Anti-TNP serum levels dropped 10-fold number antibody-forming cells spleen 30-60-fold. These results confirm special role zone processing TI-2 antigens, as earlier suggested splenectomy studies.
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