Small Molecule Inhibitor Design for Anaplastic

Huzoor Akbar, Jose Cancelas, David A. Williams, Jie Zheng, Yi Zheng, Rational Design and Applications of a Rac GTPase–Specific Small Molecule Inhibitor Methods in Enzymology. ,vol. 406, pp. 554- 565 ,(2006) , 10.1016/S0076-6879(06)06043-5

Ying Wang, Shumin Wang, Shiguang Xu, Jiaqi Qu, Bo Liu, Clinicopathologic Features of Patients with Non-Small Cell Lung Cancer Harboring the EML4-ALK Fusion Gene: A Meta-Analysis PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0110617

Yael P Mossé, Megan S Lim, Stephan D Voss, Keith Wilner, Katherine Ruffner, Julie Laliberte, Delphine Rolland, Frank M Balis, John M Maris, Brenda J Weigel, Ashish M Ingle, Charlotte Ahern, Peter C Adamson, Susan M Blaney, Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study Lancet Oncology. ,vol. 14, pp. 472- 480 ,(2013) , 10.1016/S1470-2045(13)70095-0

Erica L. Carpenter, Yael P. Mossé, Targeting ALK in neuroblastoma--preclinical and clinical advancements. Nature Reviews Clinical Oncology. ,vol. 9, pp. 391- 399 ,(2012) , 10.1038/NRCLINONC.2012.72

Yaël P Mossé, Marci Laudenslager, Luca Longo, Kristina A Cole, Andrew Wood, Edward F Attiyeh, Michael J Laquaglia, Rachel Sennett, Jill E Lynch, Patrizia Perri, Geneviève Laureys, Frank Speleman, Cecilia Kim, Cuiping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J Schork, Garrett M Brodeur, Gian P Tonini, Eric Rappaport, Marcella Devoto, John M Maris, None, Identification of ALK as a major familial neuroblastoma predisposition gene Nature. ,vol. 455, pp. 930- 935 ,(2008) , 10.1038/NATURE07261

Linda F. Epstein, Hao Chen, Renee Emkey, Douglas A. Whittington, The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase Journal of Biological Chemistry. ,vol. 287, pp. 37447- 37457 ,(2012) , 10.1074/JBC.M112.391425

Daria Zdzalik, Barbara Dymek, Paulina Grygielewicz, Pawel Gunerka, Anna Bujak, Monika Lamparska-Przybysz, Maciej Wieczorek, Karolina Dzwonek, Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma Journal of Cancer Research and Clinical Oncology. ,vol. 140, pp. 589- 598 ,(2014) , 10.1007/S00432-014-1589-3

J. Jean Cui, Michelle Tran-Dubé, Hong Shen, Mitchell Nambu, Pei-Pei Kung, Mason Pairish, Lei Jia, Jerry Meng, Lee Funk, Iriny Botrous, Michele McTigue, Neil Grodsky, Kevin Ryan, Ellen Padrique, Gordon Alton, Sergei Timofeevski, Shinji Yamazaki, Qiuhua Li, Helen Zou, James Christensen, Barbara Mroczkowski, Steve Bender, Robert S. Kania, Martin P. Edwards, Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK) Journal of Medicinal Chemistry. ,vol. 54, pp. 6342- 6363 ,(2011) , 10.1021/JM2007613

Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C. Lee, Justin F. Gainor, Adam S. Crystal, Pierre-Yves Michellys, Mark M. Awad, Noriko Yanagitani, Sungjoon Kim, AnneMarie C. Pferdekamper, Jie Li, Shailaja Kasibhatla, Frank Sun, Xiuying Sun, Su Hua, Peter McNamara, Sidra Mahmood, Elizabeth L. Lockerman, Naoya Fujita, Makoto Nishio, Jennifer L. Harris, Alice T. Shaw, Jeffrey A. Engelman, The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer Cancer Discovery. ,vol. 4, pp. 662- 673 ,(2014) , 10.1158/2159-8290.CD-13-0846

S. C. Bresler, A. C. Wood, E. A. Haglund, J. Courtright, L. T. Belcastro, J. S. Plegaria, K. Cole, Y. Toporovskaya, H. Zhao, E. L. Carpenter, J. G. Christensen, J. M. Maris, M. A. Lemmon, Y. P. Mosse, Differential Inhibitor Sensitivity of Anaplastic Lymphoma Kinase Variants Found in Neuroblastoma Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002950