Clinicopathologic Features of Patients with Non-Small Cell Lung Cancer Harboring the EML4-ALK Fusion Gene: A Meta-Analysis
作者： Ying Wang , Shumin Wang , Shiguang Xu , Jiaqi Qu , Bo Liu
DOI: 10.1371/JOURNAL.PONE.0110617
关键词:
摘要: Background The frequencies of EML4-ALK fusion gene in non-small cell lung cancer (NSCLC) with different clinicopathologic features described by previous studies are inconsistent. The key demographic and pathologic associated have not been definitively established. This meta-analysis was conducted to compare the frequency patients identify an enriched population NSCLC harboring gene. Methods Pubmed Embase databases for all on were searched up July 2014. A criteria list exclusion established screen studies. features, including smoking status, type, gender, EGFR status abstracted. Results Seventeen articles consisting 4511 cases included this meta-analysis. significant lower positive rate smokers (pooled OR = 0.40, 95% CI 0.30–0.54, P 0.05); however, because small sample size, no results regarding status. Conclusion This revealed that is highly correlated a never/light history, female type adenocarcinoma, largely mutually exclusive EGFR.
core.ac.uk
scienceopen.com
harvard.edu
science-open.com 参考文章(32)
Ying Li, Yongwen Li, Tong Yang, Sen Wei, Jing Wang, Min Wang, Yuli Wang, Qinghua Zhou, Hongyu Liu, Jun Chen, Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer PLoS ONE. ,vol. 8, pp. e52093- ,(2013) , 10.1371/JOURNAL.PONE.0052093
Takayuki Fukui, Yasushi Yatabe, Yoshihisa Kobayashi, Kenji Tomizawa, Simon Ito, Shunzo Hatooka, Keitaro Matsuo, Tetsuya Mitsudomi, Clinicoradiologic characteristics of patients with lung adenocarcinoma harboring EML4-ALK fusion oncogene Lung Cancer. ,vol. 77, pp. 319- 325 ,(2012) , 10.1016/J.LUNGCAN.2012.03.013
Yi-Wen Tsai, Tzu-I Tsai, Chung-Lin Yang, Ken N. Kuo, Gender Differences in Smoking Behaviors in an Asian Population Journal of Womens Health. ,vol. 17, pp. 971- 978 ,(2008) , 10.1089/JWH.2007.0621
Tsuyoshi Takahashi, Makoto Sonobe, Masashi Kobayashi, Akihiko Yoshizawa, Toshi Menju, Ei Nakayama, Nobuya Mino, Shotaro Iwakiri, Kiyoshi Sato, Ryo Miyahara, Kenichi Okubo, Toshiaki Manabe, Hiroshi Date, Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4 – ALK Fusion Gene Annals of Surgical Oncology. ,vol. 17, pp. 889- 897 ,(2010) , 10.1245/S10434-009-0808-7
Amanda Laura Helen Tufman, Martin Edelmann, Fernando Gamarra, Simone Reu, Astrid Borgmeier, Kathrin Schrödl, Regine Zauber, Ullrich Müller-Lisse, Rudolf Maria Huber, None, Preselection Based on Clinical Characteristics in German Non–Small-Cell Lung Cancer Patients Screened for EML4-ALK Translocation Journal of Thoracic Oncology. ,vol. 9, pp. 109- 113 ,(2014) , 10.1097/JTO.0000000000000043
Makoto Kobayashi, Tomohiro Sakakibara, Akira Inoue, Tatsuro Fukuhara, Hironobu Sasano, Masakazu Ichinose, Toshihiro Nukiwa, An effective enrichment strategy for EML4-ALK fusion gene screening in patients with non-small cell lung cancer Respiratory investigation. ,vol. 52, pp. 49- 56 ,(2014) , 10.1016/J.RESINV.2013.06.003
Daisy Wing-Sze Wong, Elaine Lai-Han Leung, Kimpton Kam-Ting So, Issan Yee-San Tam, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, Kwok-Keung Ho, Joseph Siu-Kie Au, Lap-Ping Chung, Maria Pik Wong, , The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. ,vol. 115, pp. 1723- 1733 ,(2009) , 10.1002/CNCR.24181
Kentaro Inamura, Kengo Takeuchi, Yuki Togashi, Kimie Nomura, Hironori Ninomiya, Michiyo Okui, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Manabu Soda, Young Lim Choi, Toshiro Niki, Hiroyuki Mano, Yuichi Ishikawa, EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers Journal of Thoracic Oncology. ,vol. 3, pp. 13- 17 ,(2008) , 10.1097/JTO.0B013E31815E8B60
Zhou Shaozhang, Lin Xiaomei, Zeng Aiping, He Jianbo, Song Xiangqun, Yu Qitao, Detection of EML4-ALK fusion genes in non-small cell lung cancer patients with clinical features associated with EGFR mutations. Genes, Chromosomes and Cancer. ,vol. 51, pp. 925- 932 ,(2012) , 10.1002/GCC.21976
Manabu Soda, Young Lim Choi, Munehiro Enomoto, Shuji Takada, Yoshihiro Yamashita, Shunpei Ishikawa, Shin-ichiro Fujiwara, Hideki Watanabe, Kentaro Kurashina, Hisashi Hatanaka, Masashi Bando, Shoji Ohno, Yuichi Ishikawa, Hiroyuki Aburatani, Toshiro Niki, Yasunori Sohara, Yukihiko Sugiyama, Hiroyuki Mano, None, Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer Nature. ,vol. 448, pp. 561- 566 ,(2007) , 10.1038/NATURE05945