Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?
作者： Aysegul Bayramoglu , Meral Urhan Kucuk , Halıl Ibrahim Guler , Okay Abaci , Yunus Kucukkaya
DOI: 10.1007/S10616-013-9665-0
关键词: Genotype 、 Mthfr c677t 、 Genetic predisposition 、 Matrix metalloproteinase 、 Methylenetetrahydrofolate reductase 、 Molecular biology 、 Gastroenterology 、 Gene 、 Essential hypertension 、 genomic DNA 、 Medicine 、 Internal medicine
摘要: The current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene C677T methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with 99 healthy controls) were used in study. Polymorphisms determined by using polymerase chain reaction-restriction fragment length polymorphism electrophoresis. results statistically analyzed found be significant. frequencies genotypes be, controls CC 75.8 % CT 24.2 71.2 %, 28.8 %. genotype 56.6 %, 38.4 TT 5.1 % 52 %, 30.4 % 17.6 %. In conclusion, we may suggest that no essential MMP-9 gene; on other hand (genotype TT) MTHFR can regarded as genetic indicator for development hypertension.
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