Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis
作者： Francine Grodstein , Polly A Newcomb , Meir J Stampfer
DOI: 10.1016/S0002-9343(99)00063-7
关键词: Oncology 、 Epidemiology 、 Meta-analysis 、 Internal medicine 、 Relative risk 、 Risk factor 、 Hormone therapy 、 Cancer 、 Gynecology 、 Incidence (epidemiology) 、 Medicine 、 Colorectal cancer
摘要: Abstract PURPOSE: Colorectal cancer is the fourth most common and second leading cause of death in United States. Accumulating evidence indicates that postmenopausal hormone therapy may reduce risk colorectal women. METHODS: Through MEDLINE computer searches (January 1966 to September 1998) a review references, we identified English-language articles with quantitative data on relation cancer. We reviewed studies made summary estimates relative risks (RR) by weighting results each study proportion its precision, using general variance-based, fixed-effects model. RESULTS: In our meta-analysis 18 epidemiologic cancer, found 20% reduction [RR = 0.80, 95% confidence interval (CI), 0.74 0.86] colon 19% decrease (RR 0.81, CI, 0.72 0.92) rectal for women who had ever taken compared never used hormones. Much apparent was limited current users 0.66, 0.59 0.74). CONCLUSION: Observational suggest reduced among taking There biologic support this association.
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