The relationship between the 140S antigen dose in aqueous foot-and-mouth disease vaccines and the serum antibody response of cattle

摘要: Groups of eight or 12 cattle were injected with dilutions aqueous saponized vaccines containing 329 760 to 7 ng 140S O 1 BFS 1860 strain foot-and-mouth diseas eantigen per dose. Four months later the animals subdivided into groups four and revaccinated 760, 9160 42 antigen Responses established by taking serum samples from periodically examining these for neutralizing antibody activity. The results showed that after primary vaccination dose in influenced earliest time protection, peak titres attained probably, duration immunity. At 21 days log antigen-antibody response slope was linear between 9, 160 ng, an inclination 0·53, indicating every doubling vaccine produced increase 0·16 10 SN 50 mean titre. secondary second a lesser extent first also.