Cancer stem cells and modeling cancer in the mouse

作者: Carolina Vicente-Dueñas , Elena Campos-Sanchez , Juan D. Hourcade , Isabel Romero-Camarero , Isidro Sanchez-Garcia

DOI: 10.1007/978-94-007-5645-8_22

关键词: DiseaseChronic myelogenous leukemiaGenetically Engineered MouseNeuroscienceCancer stem cellIdentification (biology)Context (language use)BiologyResponse to treatmentCancer

摘要: The complexity of cancer biology cannot be understood in all its depth solely with the study human patients and samples derived from them. These types studies are undeniably essential, but heterogeneity among patients, together long latency disease usually delayed diagnosis, make it difficult to recapitulate phases studies. In this context, genetically engineered mouse models (GEMMs) essential tools for our understanding processes leading disease. sophistication techniques allowing us model mice has increased enormously over last years, extent that we can now induce, manipulate disease, evolution response treatment a way is not possible humans. identification stem cells (CSCs) as only within tumor capacity propagating maintaining added new layer cancer. However, most GEMMs generated characterized date have being designed take into account existence CSCs their role generation, treatment. chapter briefly revise major milestones history generation cancer, propose strategies future, taking consideration what nowadays know about hierarchical nature tumors.

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