Selective metabolism of cyclodiene insecticide enantiomers by pig liver microsomal enzymes.
作者： G. T. BROOKS , S. E. LEWIS , A. HARRISON
DOI: 10.1038/2201034A0
关键词: Microsome 、 Metabolism 、 Enantiomer 、 Heptachlor Epoxide 、 Stereochemistry 、 Biotransformation 、 Biochemistry 、 Pig liver 、 Chemistry 、 Stereoisomerism 、 Heptachlor
摘要: THE molecules of several cyclodiene insecticides such as heptachlor, heptachlor epoxide, α-dihydroheptachlor1, α-chlordane and β-chlordane are asymmetrical so exist racemic modifications capable, in principle, being separated into enantiomeric forms. Such compounds contain no functional groups amenable to the usual methods for resolution modifications, their separation forms has not been effected, although these might conceivably exhibit interesting differences interaction with biological systems.
harvard.edu
nature.com
sci-hub.se 参考文章(4)
G. T. BROOKS, A. HARRISON, Structure-activity Relationships among Insecticidal Compounds derived from Chlordene Nature. ,vol. 205, pp. 1031- 1032 ,(1965) , 10.1038/2051031A0
G.T. Brooks, A. Harrison, The metabolism of some cyclodiene insecticides in relation to dieldrin resistance in the adult housefly, Musca domestica L. Journal of Insect Physiology. ,vol. 10, pp. 633- 641 ,(1964) , 10.1016/0022-1910(64)90033-2
Karl Heinz Büchel, Alfred Eduard Ginsberg, Rolf Fischer, Cyclodien-Insektizide, II. Synthese und Struktur von Heptachlor-methano-tetrahydroindanen Chemische Berichte. ,vol. 99, pp. 405- 415 ,(1966) , 10.1002/CBER.19660990207
G.T. Brooks, A. Harrison, THE EFFECT OF PYRETHRIN SYNERGISTS, ESPECIALLY SESAMEX, ON THE INSECTICIDAL POTENCY OF HEXACHLOROCYCLOPENTADIENE DERIVATIVES ("CYCLODIENE" INSECTICIDES) IN THE ADULT HOUSEFLY, MUSCA DOMESTICA L. Biochemical Pharmacology. ,vol. 13, pp. 827- 840 ,(1964) , 10.1016/0006-2952(64)90025-5