Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1

作者: J Shen , R Samul , R L Silva , H Akiyama , H Liu

DOI: 10.1038/SJ.GT.3302641

关键词: MedicineSmall interfering RNARetinalPharmacologyGenetic enhancementMessenger RNAAngiogenesisSurgeryDiabetic retinopathyChoroidal neovascularizationNeovascularization

摘要: … phosphorothioate … reactions. (b) Following 5 days in 75% oxygen, mice at P12 were returned to room air and given an intravitreous injection of 3 μg Sirna-027 or inverted control siRNA. …

参考文章(29)
JiKui Shen, Rebecca Samul, Joelle Zimmer, Hansheng Liu, Xiaoling Liang, Sean Hackett, Peter A. Campochiaro, Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization. Molecular Medicine. ,vol. 10, pp. 12- 18 ,(2004) , 10.2119/2004-00017.CAMPOCHIARO
Nancy L. Derevjanik, Peter A. Campochiaro, Melissa A. Vinores, Stanley A. Vinores, Donald J. Zack, Naoyuki Okamoto, Takao Tobe, Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors. Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 180- 188 ,(1998)
M. Graziella Persico, Placenta Growth Factor Birkhäuser, Boston, MA. pp. 301- 314 ,(2001) , 10.1007/978-1-4612-0213-4_16
C.A. Puliafito, N. Villate, P.J. Rosenfeld, E.R. McCluskey, W.J. Feuer, RhuFab V2 (Anti-VEGF Antibody Fragment) in Neovascular AMD: Safety, Tolerability, and Efficacy of Multiple, Escalating Dose Intravitreal Injections Investigative Ophthalmology & Visual Science. ,vol. 44, pp. 970- 970 ,(2003)
Shinichi Kawashima, Kei Shinoda, Susumu Ishida, Yoshihisa Oguchi, Eiji Ikeda, Yasunori Okada, Coexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1649- 1656 ,(2000)
LE Smith, Eva Wesolowski, Angela McLellan, Sandra K Kostyk, R D'amato, Richard Sullivan, Patricia Ann D'Amore, OXYGEN-INDUCED RETINOPATHY IN THE MOUSE Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 101- 111 ,(1994)
Peter A. Campochiaro, Naoyuki Okamoto, Jeanette M. Wood, Nohoon Kwak, VEGF is major stimulator in model of choroidal neovascularization. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 3158- 3164 ,(2000)
William LaRochelle, Peter A. Campochiaro, Melissa A. Vinores, Donald J. Zack, Sean F. Hackett, Naoyuki Okamoto, Hiroaki Ozaki, Takao Tobe, Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. American Journal of Pathology. ,vol. 151, pp. 281- 291 ,(1997)
Nobuyuki Kurosawa, Masaharu Ohbayashi, Yozo Miyake, Hidenori Ishihama, Takashi Muramatsu, Onrai Matsuura, Takashi Kitsukawa, Colocalization of neuropilin-1 and Flk-1 in retinal neovascularization in a mouse model of retinopathy. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 1172- 1178 ,(2001)
John E Park, Helen H Chen, Jane Winer, Keith A Houck, Napoleone Ferrara, None, Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. Journal of Biological Chemistry. ,vol. 269, pp. 25646- 25654 ,(1994) , 10.1016/S0021-9258(18)47298-5